New Constituents from the Leaves of Morinda citrifolia

Junko Takashima; Yoshitaka Ikeda; Kanki Komiyama; Masahiko Hayashi; Akio Kishida; Ayumi Ohsaki

doi:10.1248/cpb.55.343

Notes

New Constituents from the Leaves of Morinda citrifolia

Junko Takashima, Yoshitaka Ikeda, Kanki Komiyama, Masahiko Hayashi, Akio Kishida, Ayumi Ohsaki

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Keywords: Morinda citrifolia, Rubiaceae, iridoid glycoside, anthraquinone

JOURNAL FREE ACCESS

2007 Volume 55 Issue 2 Pages 343-345

DOI https://doi.org/10.1248/cpb.55.343

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Abstract

A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.

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